Exploring plant-based dengue therapeutics: from laboratory to clinic

Table 2 In vivo & in vivo/in vitro studies for pharmacologically active medicinal plants DENV infection treatment

Plant	Part used	Family	Phytocompound	Dose	Mode of action/Target protein	Reference
In vivo
*Alternanthera sessillis*	Leaves	Amaranthaceae	Tannins, polyphenols, saponins	0.2–1.0 mg/ml	Increased Platelet Count	[14]
*Carica papaya*	Leaves	Caricaceae	Carpine	15 mg/kg	Increased Platelet Count	[105]
	Leaves	Caricaceae	Flavonoids, Pseudocarpine	0.2–1.0 mg/ml	Increased Platelet Count	[14]
	Leaves	Caricaceae	Carpine, pseudocarpine, dehydrocarpine I, II	400-800 mg/kg	Enhanced platelet production
	Leaves	Caricaceae	Flavonoids	500-1000 mg/kg	Down-regulating cytokines
*Ipomea batata*	Leaves	Convolvulaceae	Anthocyanins, carotenoids, flavonoids	0.2–1.0 mg/ml	Increased Platelet Count	[14]
*Multimodal (in vivo/in vitro)*
*Azadirachta indica*	Leaves	Meliaceae	Azadirachtin	In vitro: 1.897 mg/ml In vivo: 120-130 mg/ml	Inhibits viral replication	[90]
*Curcuma longa*	Roots	Zingiberacea	Curcuminoids, α-phellandrene, terpinolene	In vitro: 17.91–85.4 µg/ml In vivo: 0.147 mg/ml	Reduces viral load	[51]
*Cissampelos pareira*	Aerial parts	Menispermacea	Terpenoids, alkaloids, tannins	In vitro:78–125 µg/ml In vivo: 2 g/kg	Down regulates TNF-α

ISSN: 2055-0936