Exploring plant-based dengue therapeutics: from laboratory to clinic

Table 3 Clinical trials/studies for pharmacologically active medicinal plants DENV infection treatment

Plant	Part used	Family	Potential Phytocompound	Dose	Mode of action/Target protein	Reference
*Carica papaya*	Leaves	Caricaceae	Flavonoids, carpine, psedocarpine, dehydrocarpine I, II	2.5 = 5 ml	Increased platelet count	[46]
	Leaves	Caricaceae	Flavonoids, carpine, psedocarpine, dehydrocarpine I, II	25 ml	Increased platelet count	[6]
	Leaves	Caricaceae	Flavonoids, carpine, psedocarpine, dehydrocarpine I, II	50 g	Up regulation of ALOX12 and PTAFR	[112]
	Leaves	Caricaceae	Flavonoids, carpine, psedocarpine, dehydrocarpine I, II	385 mg	Increased platelet count	[135]
	Leaves	Caricaceae	Flavonoids, carpine, psedocarpine, dehydrocarpine I, II	500 mg	Increased platelet count	[38]
	Leaves	Caricaceae	Flavonoids, carpine, psedocarpine, dehydrocarpine I, II	1100 mg t.i.d	Targets NS1	[106]
*Euphorbia hirta*	Aqueous extract	Euphorbiaceae	Alkanes, triterpenes, polysterols, tannins, polyphenols	Not mentioned	Increased platelet count	[77]

ISSN: 2055-0936