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Table 1 Overview of MPXV Epidemiology

From: Monkeypox: a re-emergent virus with global health implications – a comprehensive review

Year/Date

Location/Region

Clade/Lineage

Key Events

References

2018

Nigeria

West African clade

Human monkeypox identified in individuals visiting or in contact with travelers from Nigeria.

[25]

May 14, 2022

Multiple countries

Unclear origin

Clusters of mpox cases reported, no direct travel-related exposure risks.

[25]

May 18–20, 2022

Portugal, Spain, Canada, Belgium, Sweden, Italy, Australia

Clade IIb

First reported cases in several European countries and Australia during the multi-country outbreak.

[30, 32]

May 29, 2022

Global

Various clades

WHO raised a mild danger for global public health from mpox in non-endemic countries.

[32]

July 23, 2022

Global

Various clades

WHO declared the ongoing global monkeypox outbreak a public health emergency of international concern (PHEIC).

[32]

November 4, 2022

United States and globally

Various clades

CDC reported 78,229 confirmed cases and 41 deaths in 109 countries.

[33]

April 11–13, 2024

Kinshasa, Central and West Africa

Clade Ib (DRC), Clade IIa

High-level emergency meeting held to address the persistent mpox pandemic.

[27, 34]

August 19, 2024

Africa (multiple countries)

Clade Ib, Clade Ia, Clade II

WHO reported over 1,854 confirmed mpox cases in the WHO African Region, with a surge in the DRC.

[35]

July 2024

DRC, Burundi, Kenya, Rwanda, Uganda

Clade Ib

Emergence of MPXV clade Ib in new regions, associated with sexual contact and commercial sex networks.

[35]

2024

Republic of Congo, Central African Republic, Cameroon, Côte d’Ivoire, Liberia, Nigeria, South Africa

Clades Ia, IIa, IIb

Continued spread of MPXV clades across Africa, significant outbreaks affecting adults.

[35]